Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities: taxonomy, fermentation, isolation, structure elucidation and biological activites
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung
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Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities : taxonomy, fermentation, isolation, structure elucidation and biological activites. / Hellwig, Veronika; Grothe, Torsten; Mayer-Bartschmid, Anke et al.
in: Journal of Antibiotics, Jahrgang 55, Nr. 10, 01.10.2002, S. 881-892.Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung
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TY - JOUR
T1 - Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities
T2 - taxonomy, fermentation, isolation, structure elucidation and biological activites
AU - Hellwig, Veronika
AU - Grothe, Torsten
AU - Mayer-Bartschmid, Anke
AU - Endermann, Rainer
AU - Geschke, Frank-Ulrich
AU - Henkel, Thomas
AU - Stadler, Marc
PY - 2002/10/1
Y1 - 2002/10/1
N2 - A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.
AB - A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.
KW - Chemistry
UR - http://www.scopus.com/inward/record.url?scp=0036808159&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.55.881
DO - 10.7164/antibiotics.55.881
M3 - Journal articles
VL - 55
SP - 881
EP - 892
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 10
ER -