Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities: taxonomy, fermentation, isolation, structure elucidation and biological activites

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@article{e5e3d5ef8aff4e52840f2f5f5ac6b1a6,
title = "Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities: taxonomy, fermentation, isolation, structure elucidation and biological activites",
abstract = "A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.",
keywords = "Chemistry",
author = "Veronika Hellwig and Torsten Grothe and Anke Mayer-Bartschmid and Rainer Endermann and Frank-Ulrich Geschke and Thomas Henkel and Marc Stadler",
year = "2002",
month = oct,
day = "1",
doi = "10.7164/antibiotics.55.881",
language = "English",
volume = "55",
pages = "881--892",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities

T2 - taxonomy, fermentation, isolation, structure elucidation and biological activites

AU - Hellwig, Veronika

AU - Grothe, Torsten

AU - Mayer-Bartschmid, Anke

AU - Endermann, Rainer

AU - Geschke, Frank-Ulrich

AU - Henkel, Thomas

AU - Stadler, Marc

PY - 2002/10/1

Y1 - 2002/10/1

N2 - A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.

AB - A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.

KW - Chemistry

UR - http://www.scopus.com/inward/record.url?scp=0036808159&partnerID=8YFLogxK

U2 - 10.7164/antibiotics.55.881

DO - 10.7164/antibiotics.55.881

M3 - Journal articles

VL - 55

SP - 881

EP - 892

JO - Journal of Antibiotics

JF - Journal of Antibiotics

SN - 0021-8820

IS - 10

ER -

DOI