The health care system is in crisis and although the importance of nurses' mental health is widely recognized, achieving this goal is highly challenging. Promoting resilience in times of crisis appears to be a promising goal for public mental health. Innovative digital technologies to enhance resilience might contribute to a solution. Extended reality (XR) applications are highly immersive, interactive, and attractive to use. The proposed project aims to leverage the potential of XR to promote esilience in nursing staff. As resilience has a multitude of facets a prospective cohort study together with new analysis of existing large datasets will inform about those resilience factors that are the most promising target for interventions in nurses. Likewise, barriers and facilitators of acceptance of resilience training in general and XR-supported interventions in particular will be extensively considered and researched within this project. As acceptance through participation is a key success factor, a XR-supported training to foster resilience will be developed in close cooperation with nurses and other stakeholders. The proposed XR2ESILIENCE solution consists of a flexible selection of XR modules that can be customised to meet individual nurse needs. The efficacy of XR2ESILIENCE on stress coping and resilience will be investigated in a randomised controlled trial including a health economic evaluation. In addition, the project will go beyond the individual perspective and consider
organisational and structural challenges. The cohort study will enable to identify working environments where nurses can grow and enfold their resilience. Based on the results, will develop a set of recommendations and checklists for employers and policymakers that support them in making nursing facilities resilience friendly places. XR2ESILIENCE outlines a strategy for building resilience and the role of XR in resilience training.