The consequences of nuclear accidents touch many aspects of society, and thus lead to challenges for multiple actors across spatial and temporal scales. Here, we highlight unused potential of communication, collaboration and knowledge co-production for response after nuclear accidents. This potential can be harnessed by a transdisciplinary research approach including all relevant actors on a regional scale such as nuclear industry, government officials, civil society and scientific researchers. Transdisciplinary research approaches on regional scale could enhance implementation of proper mid- and long-term remediation measures and build capacity to cope up with the impacts after nuclear accidents.